Performing tablet hardness tests correctly is vital for consistent results. Follow these steps for precise and reliable measurements.
Preparation for Testing
1. Calibrate the hardness tester to standards like USP <1217>.
2. Select representative tablets from the batch.
3. Maintain a controlled environment for testing (20–25°C, 35–65% humidity).
Step-by-Step Guide
1. Position the Tablet: Place it carefully between the anvils of the tester.
2. Apply Force: Gradually increase pressure until the tablet breaks.
3. Record Data: Note the breaking force and repeat for consistency.
Optimizing the Tablet Press
Adjust the compression force and inspect punch quality to resolve hardness inconsistencies. Regular maintenance ensures uniform tablet quality.
Tips for Accuracy
1. Store tablets in a stable environment to avoid moisture damage.
2. Use clean and calibrated equipment for every batch.
3. Document results for traceability.
Accurate tablet hardness testing ensures quality and compliance. By refining the process and aligning it with tablet press performance, manufacturers can deliver superior products to the market.